Title : Correlation between GABA release from rat islet beta-cells and their metabolic state.

Pub. Date : 2002 Apr

PMID : 11882516






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Pancreatic beta-cells express glutamate decarboxylase (GAD), which is responsible for the production and release of gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid glutamate-ammonia ligase Rattus norvegicus
2 Pancreatic beta-cells express glutamate decarboxylase (GAD), which is responsible for the production and release of gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid glutamate-ammonia ligase Rattus norvegicus
3 Pancreatic beta-cells express glutamate decarboxylase (GAD), which is responsible for the production and release of gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid glutamate-ammonia ligase Rattus norvegicus
4 Pancreatic beta-cells express glutamate decarboxylase (GAD), which is responsible for the production and release of gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid glutamate-ammonia ligase Rattus norvegicus
5 Over a 24-h culture period, total GABA release by purified rat beta-cells is eightfold higher than the cellular GABA content and can thus be used as an index of cellular GAD activity. gamma-Aminobutyric Acid glutamate-ammonia ligase Rattus norvegicus
6 The notion that increased cytoplasmic ATP levels can suppress GAD activity in beta-cells, and hence GABA production and release, is compatible with previous findings on ATP suppression of brain GAD activity. gamma-Aminobutyric Acid glutamate-ammonia ligase Rattus norvegicus