Title : Lysine can be replaced by histidine but not by arginine as the ER retrieval motif for type I membrane proteins.

Pub. Date : 2002 Mar 8

PMID : 11866428






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The OST48 subunit of the oligosaccharyltransferase complex is a type I membrane protein containing three lysines in its cytosolic domain. Lysine dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Homo sapiens
2 Substitution of these lysines by arginine resulted in cell-surface expression of OST48, whereas ER residency was maintained when either Lys-5 or Lys-3 but not both was replaced with arginine. Lysine dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Homo sapiens