Pub. Date : 2002 Mar
PMID : 11861798
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Time- and concentration-dependent uptake of ACV and GCV was observed in hOAT1- and hOCT1-expressing cells. | Acyclovir | solute carrier family 22 member 6 | Homo sapiens |
| 2 | The Km values of ACV uptake by hOAT1 and hOCT1 were 342.3 and 151.2 microM, respectively, whereas those of GCV uptake by hOAT1 and hOCT1 were 895.5 and 516.2 microM, respectively. | Acyclovir | solute carrier family 22 member 6 | Homo sapiens |
| 3 | In addition, probenecid weakly inhibited the hOAT1-mediated ACV uptake. | Acyclovir | solute carrier family 22 member 6 | Homo sapiens |
| 4 | In conclusion, these results suggest that hOAT1 and hOCT1 mediate renal ACV and GCV transport, whereas hOAT1, hOAT2, hOAT3, and hOAT4 mediate renal AZT transport. | Acyclovir | solute carrier family 22 member 6 | Homo sapiens |