Pub. Date : 2002 May 31
PMID : 11856753
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II promote intramolecular interactions during glycosaminoglycan binding and thrombin inhibition. | Glycosaminoglycans | serpin family D member 1 | Homo sapiens |
2 | Interestingly, D72N/Y73F/D75N rHCII had significantly enhanced thrombin inhibition without glycosaminoglycan (4-fold greater) and with heparin (6-fold greater), showing maximal activity at 2 microg/ml heparin compared with wild-type recombinant HCII (wt-rHCII) with maximal activity at 20 microg/ml heparin. | Glycosaminoglycans | serpin family D member 1 | Homo sapiens |
3 | These results indicate that improved thrombin inhibition in the AR2 HCII mutants is mediated by enhanced interactions between the acidic domain and anion-binding exosite-1 of thrombin and that AR2 may be a "molecular rheostat" to promote thrombin inhibition in the presence of glycosaminoglycans. | Glycosaminoglycans | serpin family D member 1 | Homo sapiens |