Title : The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor.

Pub. Date : 2002 Feb 19

PMID : 11854490






3 Functional Relationships(s)
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Protein Name
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1 To identify residues that interact with the CTE, we have introduced 38 alanine substitutions for surface residues in the Tap CTE-binding domain and tested these mutants for their ability to support CTE-dependent nuclear RNA export and CTE binding. 1,1,1-trifluoro-2-chloroethane nuclear RNA export factor 1 Homo sapiens
2 To identify residues that interact with the CTE, we have introduced 38 alanine substitutions for surface residues in the Tap CTE-binding domain and tested these mutants for their ability to support CTE-dependent nuclear RNA export and CTE binding. 1,1,1-trifluoro-2-chloroethane nuclear RNA export factor 1 Homo sapiens
3 The second critical CTE-interacting surface on Tap is defined by three previously identified residues on the surface of the ribonucleoprotein domain. 1,1,1-trifluoro-2-chloroethane nuclear RNA export factor 1 Homo sapiens