Protein Name nuclear RNA export factor 1
Organism Homo sapiens
Gene ID 10482
Gene Symbol

NXF1

UniProt Q9UBU9 (NXF1_HUMAN), Q59E96 (Q59E96_HUMAN)
Relationships Total Number of functionally related compound(s) : 717
Total Number of Articles : 2729
Description

nuclear RNA export factor 1

Gene Summary

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

synonyms
  • nuclear RNA export factor 1
  • mRNA export factor TAP
  • tip associating protein
Click to show/hide the synonyms
Properties