Title : Interaction of endothelial cells and triglyceride-rich lipoproteins with apolipoprotein E (Arg-->Cys) from a patient with lipoprotein glomerulopathy.

Pub. Date : 2002 Feb

PMID : 11833049






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Interaction of endothelial cells and triglyceride-rich lipoproteins with apolipoprotein E (Arg-->Cys) from a patient with lipoprotein glomerulopathy. Cysteine apolipoprotein E Homo sapiens
2 The patient"s DNA sequence exhibited a C to G substitution in exon 3 of the apoE gene at the position of the 25th amino acid, resulting in an amino acid substitution of the arginine residue for cysteine residue. Cysteine apolipoprotein E Homo sapiens
3 These findings are consistent with the idea that an increase in binding of triglyceride-rich lipoproteins possessing apoE (Arg(25)-->Cys) to endothelial cells may promote deposition of lipid in the glomerular capillaries. Cysteine apolipoprotein E Homo sapiens