Title : Mechanotransduction of endothelial oxidative stress induced by cyclic strain.

Pub. Date : 2001

PMID : 11824481






1 Functional Relationships(s)
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1 Strain-induced luciferase activity was blunted by coincubation with RGD peptides or calphostin C. Thus, exposure of endothelial cells to cyclic strain led to integrin activation of a PKC-sensitive pathway that results in increased superoxide anion production and mobilization of NFkappaB. Superoxides nuclear factor kappa B subunit 1 Homo sapiens