Title : A co-culture-based model of human blood-brain barrier: application to active transport of indinavir and in vivo-in vitro correlation.

Pub. Date : 2002 Feb 15

PMID : 11821009






1 Functional Relationships(s)
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1 The biological relevance of this model was checked with respect on the one hand, to the close relationship between the log of drug permeability coefficient normalized to molecular weight and the log of the 1-octanol/water partition coefficient, and on the other hand to the functional P-glycoprotein (P-gp) expression. 1-Octanol ATP binding cassette subfamily B member 1 Homo sapiens