Title : Protein kinase C does not mediate the inhibitory action of lead on vitamin D3-dependent production of osteocalcin in osteoblastic bone cells.

Pub. Date : 2002 Jan 15

PMID : 11814331






2 Functional Relationships(s)
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1 To explain this clinical observation, we investigated the mechanism of action of lead on vitamin D3-dependent osteocalcin production. Cholecalciferol bone gamma-carboxyglutamate protein Homo sapiens
2 Treatment of ROS cells with Go6976, an inhibitor of PKC alpha and beta isozymes, produced similar effects as lead on vitamin D3-dependent osteocalcin production, while activation of PKC by phorbol-12-myristate-13-acetate (TPA) did not reverse or mimic this effect of lead. Cholecalciferol bone gamma-carboxyglutamate protein Homo sapiens