Title : PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway.

Pub. Date : 2002 Jan 10

PMID : 11803475






2 Functional Relationships(s)
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1 PTEN also sensitized cells to non-receptor mediated apoptosis induced by a kinase inhibitor staurosporine and chemotherapeutic agents mitoxantrone and etoposide. Staurosporine phosphatase and tensin homolog Homo sapiens
2 PTEN facilitated BID cleavage after treatment with low doses of staurosporine and mitoxantrone. Staurosporine phosphatase and tensin homolog Homo sapiens