Title : 1,25-dihydroxyvitamin D3 inhibits IFN-gamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells.

Pub. Date : 2002 Feb 1

PMID : 11801653






1 Functional Relationships(s)
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1 It has been established that the fat-soluble vitamin D(3) metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and its nuclear receptor, the vitamin D receptor, play an important role in the immune system primarily through the transcriptional inhibition of cytokine genes that either are required for Th1 differentiation or are products of differentiated Th1 cells. 1,25-dihydroxyvitamin D vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus