Protein Name vitamin D (1,25-dihydroxyvitamin D3) receptor
Organism Mus musculus
Gene ID 22337
Gene Symbol

Vdr

UniProt P48281 (VDR_MOUSE)
Relationships Total Number of functionally related compound(s) : 262
Total Number of Articles : 674
Description

vitamin D (1,25-dihydroxyvitamin D3) receptor

Gene Summary

Enables DNA binding activity and nuclear receptor activity. Involved in regulation of calcidiol 1-monooxygenase activity. Acts upstream of or within several processes, including intestinal absorption; mammary gland development; and positive regulation of apoptotic process involved in mammary gland involution. Predicted to be located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Predicted to be part of RNA polymerase II transcription regulator complex and receptor complex. Predicted to colocalize with caveola. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Used to study osteoporosis and rickets. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • vitamin D3 receptor
  • 1,25-dihydroxyvitamin D3 receptor
  • nuclear receptor subfamily 1 group I member 1
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Properties