Title : CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.

Pub. Date : 2001 Nov 21

PMID : 11792123






1 Functional Relationships(s)
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1 The utilization of the inhibitors, wortmannin and LY294002, demonstrated a role for phosphatidylinositol 3-kinase (PI3K) whereas rapamycin demonstrated p70 S6-kinase (p70S6K) involvement in the production of IL-10 by these monocytes. Sirolimus ribosomal protein S6 kinase B1 Homo sapiens