Title : Activation mechanism of Gi and Go by reactive oxygen species.

Pub. Date : 2002 Mar 15

PMID : 11781308






1 Functional Relationships(s)
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1 Although the modification of Cys(287) but not Cys(326) is required for subunit dissociation, the modification of both Cys(287) and Cys(326) is necessary for the activation of Galpha(i2) as determined by pertussis toxin-catalyzed ADP-ribosylation, conformation-dependent change of trypsin digestion pattern or guanosine 5"-3-O-(thio)triphosphate binding. Guanosine 5'-O-(3-Thiotriphosphate) succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens