Pub. Date : 2001 Jan
PMID : 11779431
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of all-trans retinoic acid and arsenic trioxide on tissue factor expression in acute promyelocytic leukemia cells. | Arsenic Trioxide | coagulation factor III, tissue factor | Homo sapiens |
| 2 | OBJECTIVE: To study the effect of all-trans retinoic acid (ATRA) and arsenic troxide (As2O3) on tissue factor (TF) expression and procoagulant activity (PCA) of acute promyelocytic leukemia (APL) cells in vivo and in vitro. | Arsenic Trioxide | coagulation factor III, tissue factor | Homo sapiens |
| 3 | OBJECTIVE: To study the effect of all-trans retinoic acid (ATRA) and arsenic troxide (As2O3) on tissue factor (TF) expression and procoagulant activity (PCA) of acute promyelocytic leukemia (APL) cells in vivo and in vitro. | Arsenic Trioxide | coagulation factor III, tissue factor | Homo sapiens |
| 4 | RESULTS: Both ATRA and As2O3 can down-regulate the TF antigen, its mRNA transcription and membrane PCA of APL cells in vivo and in vitro, in a time-dependent manner. | Arsenic Trioxide | coagulation factor III, tissue factor | Homo sapiens |
| 5 | Both ATRA and As2O3 can also down-regulate the TF antigen in U937 cells transfected with or without PML-RARa. | Arsenic Trioxide | coagulation factor III, tissue factor | Homo sapiens |
| 6 | CONCLUSION: Tissue factor expression and PCA in APL cells may be down-regulated by ATRA and As2O3. | Arsenic Trioxide | coagulation factor III, tissue factor | Homo sapiens |
| 7 | By down-regulating TF expression, As2O3 might also be used to improve the DIC-related hemorrhage in APL. | Arsenic Trioxide | coagulation factor III, tissue factor | Homo sapiens |
| 8 | The down-regulating effect of ATRA and As2O3 on TF expression in U937 cells might not involve this fusion protein. | Arsenic Trioxide | coagulation factor III, tissue factor | Homo sapiens |