Title : Bemiparin and fluid flow modulate the expression, activity and release of tissue factor pathway inhibitor in human endothelial cells in vitro.

Pub. Date : 2001 Dec

PMID : 11776326






4 Functional Relationships(s)
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1 We investigated the localisation, gene expression, and activity of tissue factor pathway inhibitor (TFPI) in endothelial cells (EC) grown in static conditions or under shear stress, in the presence of unfractionated heparin (UFH) and two low-molecular-weight heparins (LMWHs). Heparin tissue factor pathway inhibitor Homo sapiens
2 In EC grown under shear stress (0.27, 4.1 and 19 dyne/cm2) and incubated with each heparin for 24 h, the release of TFPI was significantly correlated with the level of flow for bemiparin and dalteparin, but not for UFH. Heparin tissue factor pathway inhibitor Homo sapiens
3 In EC grown under shear stress (0.27, 4.1 and 19 dyne/cm2) and incubated with each heparin for 24 h, the release of TFPI was significantly correlated with the level of flow for bemiparin and dalteparin, but not for UFH. Heparin tissue factor pathway inhibitor Homo sapiens
4 The expression of TFPI mRNA, determined by Northern blotting, was specifically modulated by heparins. Heparin tissue factor pathway inhibitor Homo sapiens