Title : Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes.

Pub. Date : 2002 Jan

PMID : 11773860






3 Functional Relationships(s)
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1 In humans, PAPS is synthesized from adenosine 5"-triphosphate (ATP) and inorganic sulfate (SO2-4) by two isoforms, PAPSS1 and PAPSS2. Sulfates 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Homo sapiens
2 To determine whether more common genetic polymorphisms that do not completely inactivate the enzyme might be one factor responsible for individual differences in sulfate conjugation, we previously cloned the human PAPSS2 gene. Sulfates 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Homo sapiens
3 It will now be possible to test the hypothesis that these common, functionally significant PAPSS2 genetic polymorphisms might contribute to variations in sulfate conjugation in vivo. Sulfates 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Homo sapiens