Protein Name 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Organism Homo sapiens
Gene ID 9060
Gene Symbol


UniProt O95340 (PAPS2_HUMAN), Q5TB52 (Q5TB52_HUMAN)
Relationships Total Number of functionally related compound(s) : 25
Total Number of Articles : 25

3'-phosphoadenosine 5'-phosphosulfate synthase 2

Gene Summary

Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

  • bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
  • 3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2
  • ATP sulfurylase/APS kinase 2
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