Title : Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor.

Pub. Date : 2002 Jan 8

PMID : 11772005






4 Functional Relationships(s)
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1 Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor. Heparin tissue factor pathway inhibitor Homo sapiens
2 Tissue factor pathway inhibitor (TFPI) inhibits the activity of coagulation factor VIIa and Xa through its K1 and K2 domain, respectively, and the inhibitory activity is enhanced by heparin. Heparin tissue factor pathway inhibitor Homo sapiens
3 Tissue factor pathway inhibitor (TFPI) inhibits the activity of coagulation factor VIIa and Xa through its K1 and K2 domain, respectively, and the inhibitory activity is enhanced by heparin. Heparin tissue factor pathway inhibitor Homo sapiens
4 It is likely that heparin simply increases the local concentration of TFPI on the cell surface and stabilizes the initial complex that forms. Heparin tissue factor pathway inhibitor Homo sapiens