Pub. Date : 2001 Nov
PMID : 11765139
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The inhibition of recombinant CYP1A1 and CYP1A2 activity by quinidine and quinine was evluated using ethoxyresorutin O-deethylation, phenacetin O-deethylation and propranolol desisopropylation as probe catalytic pathways. | Quinine | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 2 | With substrate concentrations near the Km of catalysis, both quinidine and quinine potently inhibited CYP1A1 activity with [I](0.5) approximately 1-3 microM, whereas in contrast, there was little inhibition of CYP1A2 activity. | Quinine | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |