Title : Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin.

Pub. Date : 2001 Dec 15

PMID : 11755111






1 Functional Relationships(s)
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1 Notably, the S(+)-isomer of ibuprofen was 32-, 41-, and 96-fold more potent than the R(-)-isomer for the inhibition of PGHS-1 activity, human platelet aggregation, and serotonin secretion, respectively. Ibuprofen prostaglandin-endoperoxide synthase 1 Homo sapiens