Title : Expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae reveals a functional role in aflatoxin B1 detoxification.

Pub. Date : 2002 Jan

PMID : 11752683






3 Functional Relationships(s)
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1 Coexpression of mEH with CYP1A1 or CYP1A2 resulted in significant decreases in measurements of AFB genotoxicity. Aflatoxin B1 cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 The mutagenicity of AFB in the Ames assay was also decreased by approximately 50% when AFB was incubated with microsomes containing CYP1A1 or CYP1A2 and mEH versus CYP1A1 or CYP1A2 alone. Aflatoxin B1 cytochrome P450 family 1 subfamily A member 1 Homo sapiens
3 The mutagenicity of AFB in the Ames assay was also decreased by approximately 50% when AFB was incubated with microsomes containing CYP1A1 or CYP1A2 and mEH versus CYP1A1 or CYP1A2 alone. Aflatoxin B1 cytochrome P450 family 1 subfamily A member 1 Homo sapiens