Title : Direct interaction of the Krüppel-like family (KLF) member, BTEB1, and PR mediates progesterone-responsive gene expression in endometrial epithelial cells.

Pub. Date : 2002 Jan

PMID : 11751593






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 GAL4/PR-B and VP16/PR-B induced ( approximately 3- to 4-fold) chloramphenicol acetyltransferase (CAT) activity in a progesterone-dependent manner, suggesting PR-dimer formation. Progesterone RB transcriptional corepressor 1 Homo sapiens
2 GAL4/PR-B and VP16/PR-B induced ( approximately 3- to 4-fold) chloramphenicol acetyltransferase (CAT) activity in a progesterone-dependent manner, suggesting PR-dimer formation. Progesterone RB transcriptional corepressor 1 Homo sapiens
3 Together, these findings support the conclusion that BTEB1 and PR-B are coregulatory proteins that mediate progesterone responsiveness of target genes by direct interactions, leading to the formation of a functional BTEB1/PR-dimer complex. Progesterone RB transcriptional corepressor 1 Homo sapiens