Title : Inhibition of CD28-mediated natural cytotoxicity by KIR2DL2 does not require p56(lck) in the NK cell line YT-Indy.

Pub. Date : 2002 Jan

PMID : 11750651






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CD28 crosslinking on YT-Indy-cl43 enhanced tyrosine phosphorylation of PLC-gamma1. Tyrosine phospholipase C gamma 1 Homo sapiens
2 The simultaneous ligation of KIR2DL2 with mAb resulted in a decrease in CD28-induced tyrosine phosphorylation of PLC-gamma1 confirming that dephosphorylation of this protein is involved in the KIR2DL2-induced inhibition of CD28-mediated cytotoxicity. Tyrosine phospholipase C gamma 1 Homo sapiens