Title : PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts.

Pub. Date : 2002 Jan

PMID : 11742805






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) dose-dependently decreased LPS-induced cyclooxygenase (COX)-2 (-80%) and inducible nitric oxide synthase (iNOS) mRNA expression (-80%), whereas troglitazone (10 microM) only inhibited iNOS mRNA expression (-50%). 15-deoxy-delta nitric oxide synthase 2 Rattus norvegicus
2 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) dose-dependently decreased LPS-induced cyclooxygenase (COX)-2 (-80%) and inducible nitric oxide synthase (iNOS) mRNA expression (-80%), whereas troglitazone (10 microM) only inhibited iNOS mRNA expression (-50%). 15-deoxy-delta nitric oxide synthase 2 Rattus norvegicus
3 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) dose-dependently decreased LPS-induced cyclooxygenase (COX)-2 (-80%) and inducible nitric oxide synthase (iNOS) mRNA expression (-80%), whereas troglitazone (10 microM) only inhibited iNOS mRNA expression (-50%). 15-deoxy-delta nitric oxide synthase 2 Rattus norvegicus