Title : Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices.

Pub. Date : 2001 Nov

PMID : 11723184






2 Functional Relationships(s)
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1 In order to assess a role of 5-HT(1B) receptors for regulation of GABA transmission in the ventral tegmental area (VTA), VTA slices from the rat were incubated with [(3)H]GABA and beta-alanine, and superfused in the presence of nipecotic acid and aminooxyacetic acid. gamma-Aminobutyric Acid 5-hydroxytryptamine receptor 1B Rattus norvegicus
2 The results support the hypothesis that 5-HT(1B) receptors within the VTA can function as heteroreceptors to inhibit GABA release. gamma-Aminobutyric Acid 5-hydroxytryptamine receptor 1B Rattus norvegicus