Title : Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding.

Pub. Date : 2001 Nov 16

PMID : 11719190






1 Functional Relationships(s)
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1 We show that immature CD4(+)CD8(+) double-positive thymocytes bind MHCI tetramers more avidly than mature CD8 single-positive thymocytes, and that this differential binding is governed by developmentally programmed O-glycan modification controlled by the ST3Gal-I sialyltransferase. o-glycan CD8a molecule Homo sapiens