PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11719190-3 2001 We show that immature CD4(+)CD8(+) double-positive thymocytes bind MHCI tetramers more avidly than mature CD8 single-positive thymocytes, and that this differential binding is governed by developmentally programmed O-glycan modification controlled by the ST3Gal-I sialyltransferase. o-glycan 215-223 CD8a molecule Homo sapiens 28-31