Title : Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2.

Pub. Date : 2001 Dec

PMID : 11714871






1 Functional Relationships(s)
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1 The inactivation of liver microsomal CYP1A2 by trans-resveratrol required NADPH, was not reversible by dialysis, and was not affected by the trapping agents glutathione, N-acetylcysteine, catalase, or superoxide dismutase, but was attenuated by a CYP1A2 substrate, imipramine. Imipramine cytochrome P450 family 1 subfamily A member 2 Homo sapiens