Title : ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth.

Pub. Date : 2001 Nov 8

PMID : 11709727






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Furthermore, treatment with LY294002 resulted in the selective increase of cyclin-dependent kinase inhibitors p21(Cip1) or p27(Kip1) and suppression of cyclin E-associated Cdk2 kinase activity in ErbB2-overexpressing lines, which may account for their hypersensitivity toward inhibitors of the PI3K pathway in anchorage-independent growth. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one cyclin dependent kinase inhibitor 1B Homo sapiens