Pub. Date : 2001 Oct
PMID : 11706391
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have recently shown that trastuzumab can effectively sensitize ErbB2-overexpressing breast cancer cells to paclitaxel by reversing the antiapoptotic function of ErbB2. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | Mechanisms of ErbB2-mediated paclitaxel resistance and trastuzumab-mediated paclitaxel sensitization in ErbB2-overexpressing breast cancers. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | Mechanisms of ErbB2-mediated paclitaxel resistance and trastuzumab-mediated paclitaxel sensitization in ErbB2-overexpressing breast cancers. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | Although controversies exist, data from our laboratory and from clinical trials of trastuzumab indicate that ErbB2 overexpression confers chemoresistance to certain chemotherapeutic agents such as paclitaxel. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 5 | One of the molecular mechanisms of ErbB2-mediated paclitaxel resistance is that overexpression of the ErbB2 receptor leads to deregulation of the G2/M cell cycle check-point that inhibits paclitaxel-induced apoptosis. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 6 | One of the molecular mechanisms of ErbB2-mediated paclitaxel resistance is that overexpression of the ErbB2 receptor leads to deregulation of the G2/M cell cycle check-point that inhibits paclitaxel-induced apoptosis. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 7 | One of the molecular mechanisms of ErbB2-mediated paclitaxel resistance is that overexpression of the ErbB2 receptor leads to deregulation of the G2/M cell cycle check-point that inhibits paclitaxel-induced apoptosis. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 8 | One of the molecular mechanisms of ErbB2-mediated paclitaxel resistance is that overexpression of the ErbB2 receptor leads to deregulation of the G2/M cell cycle check-point that inhibits paclitaxel-induced apoptosis. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 9 | Several promising ErbB2-targeting strategies have now been developed to conquer the adverse consequences of ErbB2 overexpression such as paclitaxel resistance. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 10 | Several promising ErbB2-targeting strategies have now been developed to conquer the adverse consequences of ErbB2 overexpression such as paclitaxel resistance. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 11 | We have recently shown that trastuzumab can effectively sensitize ErbB2-overexpressing breast cancer cells to paclitaxel by reversing the antiapoptotic function of ErbB2. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |