Pub. Date : 2002 Jan 18
PMID : 11698395
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, apicidin converted the procaspase-3 form to catalytically active effector protease, resulting in subsequent cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1). | apicidin | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | Incubation of HL60 cells with z-DEVD-fmk, a caspase-3 inhibitor, almost completely abrogated apicidin-induced activation of caspase-3, DNA fragmentation, and cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1). | apicidin | poly(ADP-ribose) polymerase 1 | Homo sapiens |