Title : Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium.

Pub. Date : 2001 Nov 16

PMID : 11689167






3 Functional Relationships(s)
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1 Rotenone-induced activation of caspase-3 was enhanced by inhibition of PI3K or increased GSK3beta activity, and was attenuated by inhibiting GSK3beta with lithium. Rotenone glycogen synthase kinase 3 beta Homo sapiens
2 Rotenone-induced activation of caspase-3 was enhanced by inhibition of PI3K or increased GSK3beta activity, and was attenuated by inhibiting GSK3beta with lithium. Rotenone glycogen synthase kinase 3 beta Homo sapiens
3 Overall, these results indicate that inhibition of GSK3beta provides protection against the toxic effects of agents, such as MPP and rotenone, that impair mitochondrial function. Rotenone glycogen synthase kinase 3 beta Homo sapiens