Title : Cytotoxicity and effect on collagen biosynthesis of proline analogue of melphalan as a prolidase-convertible prodrug in cultured human skin fibroblasts.

Pub. Date : 2001 Sep

PMID : 11680815






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Proline analogue of melphalan (MEL-PRO) was synthesised as a prodrug susceptible to the action of ubiquitously distributed, cytosolic imidodipeptidase--prolidase [E.C.3.4.13.9]. Melphalan peptidase D Homo sapiens
2 Conjugation of melphalan (MEL) with proline (PRO) through an imido-bond resulted in formation of a good substrate for prolidase. Melphalan peptidase D Homo sapiens