Protein Name peptidase D
Organism Homo sapiens
Gene ID 5184
Gene Symbol


UniProt P12955 (PEPD_HUMAN), A0A140VJR2 (A0A140VJR2_HUMAN)
Relationships Total Number of functionally related compound(s) : 202
Total Number of Articles : 212

peptidase D

Gene Summary

This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

  • xaa-Pro dipeptidase
  • X-Pro dipeptidase
  • aminoacyl-L-proline hydrolase
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