Title : Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor.

Pub. Date : 2002 Jan 4

PMID : 11679585






2 Functional Relationships(s)
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1 In previous work, we have shown that CYP2C9 is inducible in primary human hepatocytes by xenobiotics including dexamethasone, rifampicin, and phenobarbital. Phenobarbital cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 Identification of these functional elements provides rational mechanistic basis for CYP2C9 induction by dexamethasone (submicromolar concentrations), and by phenobarbital and rifampicin, respectively. Phenobarbital cytochrome P450 family 2 subfamily C member 9 Homo sapiens