Pub. Date : 2001 Oct
PMID : 11668420
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Molecular weight-dependent influence of heparin on the form of tissue factor pathway inhibitor circulating in plasma. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 2 | The increase of circulating tissue factor pathway inhibitor (TFPI) in plasma by heparins is thought to contribute to their overall antithrombotic activity. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 3 | The increase of circulating tissue factor pathway inhibitor (TFPI) in plasma by heparins is thought to contribute to their overall antithrombotic activity. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 4 | In a clinical study in healthy volunteers, we recently found that the specific potency of a heparin to mobilize TFPI from the vessel wall increases with its molecular weight (MW). | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 5 | A further question is whether the MW of heparin influences not only the release of TFPI but also its potential association with lipoproteins. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 6 | Only the TFPI released by unfractionated heparin (UFH) circulated completely as free TFPI. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 7 | Only the TFPI released by unfractionated heparin (UFH) circulated completely as free TFPI. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 8 | With decreasing heparin MW, the percentage of released free TFPI on released total TFPI decreased to 57%. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 9 | With decreasing heparin MW, the percentage of released free TFPI on released total TFPI decreased to 57%. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 10 | As a consequence, the longer the heparin chains are, the better they are at preventing the binding of the released, originally free, TFPI to plasma lipoproteins. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 11 | Because only free TFPI is known to exhibit anticoagulant activity, the activity of released TFPI is better the higher the MW of the applied heparin is. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 12 | Because only free TFPI is known to exhibit anticoagulant activity, the activity of released TFPI is better the higher the MW of the applied heparin is. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 13 | In conclusion, in addition to the potency of heparin to mobilize TFPI, there is its influence on the circulating form, and thus the anticoagulant activity of the released TFPI depends on its MW. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 14 | In conclusion, in addition to the potency of heparin to mobilize TFPI, there is its influence on the circulating form, and thus the anticoagulant activity of the released TFPI depends on its MW. | Heparin | tissue factor pathway inhibitor | Homo sapiens |