Title : Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity.

Pub. Date : 2001 Dec 21

PMID : 11604391






2 Functional Relationships(s)
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1 ACE also significantly inhibited A beta cytotoxicity on PC12 h. The most striking fact was that ACE degraded A beta by cleaving A beta-(1-40) at the site Asp(7)-Ser(8). Aspartic Acid amyloid beta precursor protein Homo sapiens
2 ACE also significantly inhibited A beta cytotoxicity on PC12 h. The most striking fact was that ACE degraded A beta by cleaving A beta-(1-40) at the site Asp(7)-Ser(8). Aspartic Acid amyloid beta precursor protein Homo sapiens