Title : Hierarchical protein folding: asymmetric unfolding of an insulin analogue lacking the A7-B7 interchain disulfide bridge.

Pub. Date : 2001 Oct 16

PMID : 11591149






3 Functional Relationships(s)
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1 Hierarchical protein folding: asymmetric unfolding of an insulin analogue lacking the A7-B7 interchain disulfide bridge. Disulfides insulin Homo sapiens
2 Stepwise stabilization of structural subdomains among on-pathway intermediates is proposed to underlie the disulfide pathway of proinsulin and related molecules. Disulfides insulin Homo sapiens
3 Here, effects of pairwise serine substitution of insulin"s exposed interchain disulfide bridge (Cys(A7)-Cys(B7)) are characterized as a model of a late intermediate. Disulfides insulin Homo sapiens