Title : Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones.

Pub. Date : 2001 Aug

PMID : 11587640






1 Functional Relationships(s)
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1 RESULTS: Here we report the high-resolution crystal structures of complexes of QR1 with three chemotherapeutic prodrugs: RH1, a water-soluble homolog of dimethylaziridinylbenzoquinone; EO9, an aziridinylindolequinone; and ARH019, another aziridinylindolequinone. Water NAD(P)H quinone dehydrogenase 1 Homo sapiens