Title : RhoGDI-binding-defective mutant of Cdc42Hs targets to membranes and activates filopodia formation but does not cycle with the cytosol of mammalian cells.

Pub. Date : 2001 Oct 15

PMID : 11583574






1 Functional Relationships(s)
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1 We have identified a mutant of the human G-protein Cdc42Hs, R66E, that fails to form a detectable complex with the GDP-dissociation inhibitor RhoGDI in cell-free systems or in intact cells. Guanosine Diphosphate cell division cycle 42 Homo sapiens