Title : Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogen-activated protein kinase.

Pub. Date : 2001 Sep 28

PMID : 11577023






2 Functional Relationships(s)
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Protein Name
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1 Inhibition of Rho A by C3 exoenzyme (20 microgram/mL) and ROCK by Y-27632 (10 micromol/L) prevented the downregulation of eNOS expression by thrombin. Y 27632 coagulation factor II, thrombin Homo sapiens
2 Y-27632 also prevented the reduction in NOS activity induced by prolonged incubation with thrombin. Y 27632 coagulation factor II, thrombin Homo sapiens