Title : Synthesis and evaluation of diazine containing bioisosteres of (-)-ferruginine as ligands for nicotinic acetylcholine receptors.

Pub. Date : 2001 Oct

PMID : 11557356






1 Functional Relationships(s)
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1 The bioisosteric replacement of the acetyl moiety as structural part of the lead compound 3 with the pyridazine, pyrimidine and pyrazine nucleus resulted in ligands with high to moderate affinity for the central alpha4beta2 and remarkably low affinity for the alpha7* nAChR subtypes. Pyrazines cholinergic receptor nicotinic alpha 4 subunit Homo sapiens