Pub. Date : 2001 Sep
PMID : 11532855
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OGG1 was cloned as a human gene encoding a DNA glycosylase that specifically excises 8-OHG from DNA in vitro. | 8-ohg | 8-oxoguanine DNA glycosylase | Homo sapiens |
| 2 | In the present study we have examined the ability of OGG1 protein to suppress G:C-->T:A transversions caused by 8-OHG in human cells by bacterial suppressor tRNA (supF) forward mutation assay using a shuttle vector DNA, pMY189. | 8-ohg | 8-oxoguanine DNA glycosylase | Homo sapiens |
| 3 | The mutation frequency of the 8-OHG-containing plasmid was significantly reduced by overexpression of OGG1 protein in NCI-H1299 cells and, in particular, the occurrence of G:C-->T:A transversion at position 159 in the supF gene was suppressed. | 8-ohg | 8-oxoguanine DNA glycosylase | Homo sapiens |
| 4 | These results indicate that OGG1 protein has the ability to suppress G:C-->T:A transversions caused by 8-OHG in human cells in vivo. | 8-ohg | 8-oxoguanine DNA glycosylase | Homo sapiens |