Title : Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy.

Pub. Date : 2001 Aug

PMID : 11514617






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Expression of the Cas-binding proline-rich region 1 of FAK hindered association of Cas with FAK and impaired the structural stability of sarcomeres. Proline protein tyrosine kinase 2 Homo sapiens
2 Expression of the Cas-binding proline-rich region 1 of FAK hindered association of Cas with FAK and impaired the structural stability of sarcomeres. Proline protein tyrosine kinase 2 Homo sapiens
3 Moreover, expression of the focal adhesion-targeting and/or the Cas-binding proline-rich regions of FAK inhibited ANP promoter activity and suppressed ET-induced ANP and brain natriuretic peptide gene expression. Proline protein tyrosine kinase 2 Homo sapiens