Title : Neuroendocrine serotonergic and dopaminergic responsivity in male schizophrenic patients during treatment with neuroleptics and after switch to risperidone.

Pub. Date : 2001 Aug

PMID : 11512043






5 Functional Relationships(s)
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1 METHODS: Two neuroendocrine challenge tests, measuring the PRL increases induced by acute administration of serotonergic (clomipramine, 25 mg i.v.) Clomipramine prolactin Homo sapiens
2 PRL was estimated in blood samples taken every 15 min for 1 h for clomipramine and every 30 min for 2 h for haloperidol. Clomipramine prolactin Homo sapiens
3 In contrast, the PRL increases obtained after clomipramine administration during neuroleptic treatment were preserved after treatment with risperidone. Clomipramine prolactin Homo sapiens
4 Both PRL response patterns to clomipramine were similar to that of healthy controls. Clomipramine prolactin Homo sapiens
5 CONCLUSIONS: During treatment with typical neuroleptics, the PRL responses to clomipramine are normal, and they are preserved after switch to risperidone in doses that cause complete dopamine receptor blockade. Clomipramine prolactin Homo sapiens