Title : Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones.

Pub. Date : 2001 Oct 26

PMID : 11500489






1 Functional Relationships(s)
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1 Contrary to previous reports, we show that parthenolide, like other SLs, inhibits NF-kappaB most probably by alkylating p65 at Cys(38). parthenolide RELA proto-oncogene, NF-kB subunit Homo sapiens