Title : Novel site in lipoprotein lipase (LPL415;-438) essential for substrate interaction and dimer stability.

Pub. Date : 2001 Aug

PMID : 11483618






2 Functional Relationships(s)
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1 LPL, like other lipases, has the ability to hydrolyze water-insoluble lipid substrates, but the mechanism is incompletely understood. Water lipoprotein lipase Homo sapiens
2 Specific point mutations or deletion of the region between the hydrophobic stretches (LPL419-430) caused up to 90% selective loss of hydrolyzing activity against water-insoluble triolein, but not against water-soluble tributyrin, implicating a crucial function for LPL419-430 in the interaction with lipid substrates. Water lipoprotein lipase Homo sapiens