Title : Postglomerular vasoconstriction to angiotensin II and norepinephrine depends on intracellular calcium release.

Pub. Date : 2000 Jun

PMID : 11483290






7 Functional Relationships(s)
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1 The current study was performed to determine the effect of calcium store depletion with cyclopiazonic acid (CPA) on the pre- and postglomerular vasoconstrictor responses to angiotensin II (ANG II) and norepinephrine (NE). cyclopiazonic acid angiotensinogen Homo sapiens
2 The current study was performed to determine the effect of calcium store depletion with cyclopiazonic acid (CPA) on the pre- and postglomerular vasoconstrictor responses to angiotensin II (ANG II) and norepinephrine (NE). cyclopiazonic acid angiotensinogen Homo sapiens
3 The current study was performed to determine the effect of calcium store depletion with cyclopiazonic acid (CPA) on the pre- and postglomerular vasoconstrictor responses to angiotensin II (ANG II) and norepinephrine (NE). cyclopiazonic acid angiotensinogen Homo sapiens
4 The current study was performed to determine the effect of calcium store depletion with cyclopiazonic acid (CPA) on the pre- and postglomerular vasoconstrictor responses to angiotensin II (ANG II) and norepinephrine (NE). cyclopiazonic acid angiotensinogen Homo sapiens
5 CPA treatment significantly attenuated the afferent arteriolar response to 10 nM ANG II by 51% and to 1000 nM NE by 19%. cyclopiazonic acid angiotensinogen Homo sapiens
6 Efferent arteriolar responses to ANG II and NE were also greatly attenuated in the presence of CPA. cyclopiazonic acid angiotensinogen Homo sapiens
7 These data demonstrate that afferent and efferent arteriolar responses to ANG II and NE depend on release of calcium from CPA-sensitive intracellular stores. cyclopiazonic acid angiotensinogen Homo sapiens